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1

Oxidant stress, mitochondria, and cell death mechanisms in drug-induced liver injury: Lessons learned from acetaminophen hepatotoxicity

Jaeschke, Hartmut, McGill, Mitchell R., Ramachandran, Anup

Journal:

Drug Metabolism Reviews

Year:

2012

Language:

english

File:

PDF, 1.15 MB

english, 2012

2

Letter to the Editor Regarding the Article “The Chrysin effect in prevention of acetaminophen-induced hepatotoxicity in rat” by Mohammadi and Coworkers (2019)

Jaeschke, Hartmut, Ramachandran, Anup

Journal:

Chemical Research in Toxicology

Year:

2020

Language:

english

File:

PDF, 790 KB

english, 2020

3

Reactive oxygen species in the normal and acutely injured liver

Hartmut Jaeschke, Anup Ramachandran

Journal:

Journal of Hepatology

Year:

2011

Language:

english

File:

PDF, 698 KB

english, 2011

4

Manual Platelet Counts are Significantly Higher than Coulter Platelet Counts in Portal Hypertension

Prasanna, K.S., Goel, Ashish, Ramachandran, Anup, Balasubramaniam, K.A., Ragupathy, V., Mammen, Joy, Elias, Elwyn, Eapen, C.E.

Journal:

Journal of Clinical and Experimental Hepatology

Year:

2014

Language:

english

File:

PDF, 90 KB

english, 2014

5

Raised plasma levels of H2S and nitrate predict intrapulmonary vascular dilations: A preliminary report in patients with cryptogenic cirrhosis

Bera, Chinmay, Thangaraj, Kavitha, Pati, Purendra Kumar, Ramachandran, Jeyamani, Balasubramanian, K A, Ramachandran, Anup, Zachariah, Uday, Sajith, K G, Goel, Ashish, Eapen, C E

Journal:

Indian Journal of Gastroenterology

Year:

2018

Language:

english

File:

PDF, 508 KB

english, 2018

6

Mito-tempo protects against acute liver injury but induces limited secondary apoptosis during the late phase of acetaminophen hepatotoxicity

Du, Kuo, Ramachandran, Anup, Weemhoff, James L., Woolbright, Benjamin L., Jaeschke, Andrew H., Chao, Xiaojuan, Ding, Wen-Xing, Jaeschke, Hartmut

Journal:

Archives of Toxicology

Year:

2018

Language:

english

File:

PDF, 16.17 MB

english, 2018

7

The role of oxidant stress in acetaminophen-induced liver injury

Jaeschke, Hartmut, Ramachandran, Anup

Journal:

Current Opinion in Toxicology

Year:

2020

File:

PDF, 1.06 MB

2020

8

Novel strategies for the treatment of acetaminophen hepatotoxicity

Akakpo, Jephte Y., Ramachandran, Anup, Jaeschke, Hartmut

Journal:

Expert Opinion on Drug Metabolism & Toxicology

Year:

2020

File:

PDF, 1.17 MB

2020

9

4-methylpyrazole protects against acetaminophen-induced acute kidney injury

Akakpo, Jephte Y., Ramachandran, Anup, Orhan, Hilmi, Curry, Steven C., Rumack, Barry H., Jaeschke, Hartmut

Journal:

Toxicology and Applied Pharmacology

Year:

2020

File:

PDF, 6.29 MB

2020

10

High throughput two-dimensional blue-native electrophoresis: A tool for functional proteomics of mitochondria and signaling complexes

Paul S. Brookes, Anita Pinner, Anup Ramachandran, Lori Coward, Stephen Barnes, Helen Kim, Victor M. Darley-Usmar

Journal:

Year:

2002

Language:

english

File:

PDF, 196 KB

english, 2002

11

Intestinal mucosal alterations in rats with carbon tetrachloride-induced cirrhosis: Changes in glycosylation and luminal bacteria

Sathish Kumar Natarajan, Prabhu Ramamoorthy, Simmy Thomas, Jayasree Basivireddy, Gagandeep Kang, Anup Ramachandran, Anna B Pulimood, K.A. Balasubramanian

Journal:

Year:

2006

Language:

english

File:

PDF, 560 KB

english, 2006

12

Renal damage in experimentally-induced cirrhosis in rats: Role of oxygen free radicals

Sathish Kumar Natarajan, Jayasree Basivireddy, Anup Ramachandran, Simmy Thomas, Prabhu Ramamoorthy, Anna B. Pulimood, Molly Jacob, Kunissery A. Balasubramanian

Journal:

Year:

2006

Language:

english

File:

PDF, 745 KB

english, 2006

13

Liver injury in acute fatty liver of pregnancy: Possible link to placental mitochondrial dysfunction and oxidative stress

Sathish Kumar Natarajan, Kavitha R. Thangaraj, C. E. Eapen, Anup Ramachandran, Ashis Mukhopadhya, Mathews Mathai, Lakshmi Seshadri, Abraham Peedikayil, Banumathi Ramakrishna, Kunnissery A. Balasubrama

Journal:

Year:

2010

Language:

english

File:

PDF, 349 KB

english, 2010

14

HepaRG cells: A human model to study mechanisms of acetaminophen hepatotoxicity

Mitchell R. McGill, Hui-Min Yan, Anup Ramachandran, Gordon J. Murray, Douglas E. Rollins, Hartmut Jaeschke

Journal:

Year:

2011

Language:

english

File:

PDF, 4.03 MB

english, 2011

15

Nitric oxide production in acute gastroenteritis in Indian children

Thuppal Varadachari Sowmyanarayanan, Sathish Kumar Natarajan, Anup Ramachandran, Rajiv Sarkar, Prabhakar Devarajan Moses, Anna Simon, Indira Agarwal, Solomon Christopher, Gagandeep Kang

Journal:

Transactions of the Royal Society of Tropical Medicine and Hygiene

Year:

2009

Language:

english

File:

PDF, 150 KB

english, 2009

16

Apoptosis in the intestinal epithelium: Its relevance in normal and pathophysiological conditions

Anup Ramachandran, Muniswamy Madesh, Kunissery A Balasubramanian

Journal:

Journal of Gastroenterology and Hepatology

Year:

2000

Language:

english

File:

PDF, 429 KB

english, 2000

17

Intestinal dysfunction in liver cirrhosis: Its role in spontaneous bacterial peritonitis

Anup Ramachandran, Kunnissery A Balasubramanian

Journal:

Journal of Gastroenterology and Hepatology

Year:

2001

Language:

english

File:

PDF, 157 KB

english, 2001

18

Mild Whole-Body Heat Stress Alters Retinoid Metabolism in the Rat Small Intestine

Prabhu Ramamoorthy, Simmy Thomas, Anup Ramachandran, Kunissery A. Balasubramanian

Journal:

Digestive Diseases and Sciences

Year:

2006

Language:

english

File:

PDF, 157 KB

english, 2006

19

Locally made ready-to-use therapeutic food for treatment of malnutrition:A randomized controlled trial

Azara Sneha Singh, Gagandeep Kang, Anup Ramachandran, Rajiv Sarkar, Pearline Peter, Anuradha Bose

Journal:

Indian Pediatrics

Year:

2010

Language:

english

File:

PDF, 143 KB

english, 2010

20

Oxidative stress in the development of liver cirrhosis: A comparison of two different experimental models

Sathish Kumar Natarajan, Simmy Thomas, Prabhu Ramamoorthy, Jayasree Basivireddy, Anna B Pulimood, Anup Ramachandran, Kunissery A Balasubramanian

Journal:

Journal of Gastroenterology and Hepatology

Year:

2006

Language:

english

File:

PDF, 680 KB

english, 2006

21

Spontaneous bacterial peritonitis results in oxidative and nitrosative stress in ascitic fluid

Sathish Kumar Natarajan, Ashis Mukhopadhya, Anup Ramachandran, Sophia Amalanathan, George Kurian, Kunissery A Balasubramanian

Journal:

Journal of Gastroenterology and Hepatology

Year:

2007

Language:

english

File:

PDF, 98 KB

english, 2007

22

Retinoid metabolism in the small intestine during development of liver cirrhosis

Sathish Kumar Natarajan, G Jayakumar Amirtharaj, Anup Ramachandran, Anna B Pulimood, Kunissery A Balasubramanian

Journal:

Journal of Gastroenterology and Hepatology

Year:

2009

Language:

english

File:

PDF, 610 KB

english, 2009

23

Acetaminophen hepatotoxicity and repair: the role of sterile inflammation and innate immunity

Hartmut Jaeschke, C. David Williams, Anup Ramachandran, Mary L. Bajt

Journal:

Liver International

Year:

2012

Language:

english

File:

PDF, 1.03 MB

english, 2012

24

Intestinal mucosal alterations in experimental cirrhosis in the rat: Role of oxygen free radicals

Anup Ramachandran, Ramamoorthy Prabhu, Simmy Thomas, Jayasree Basivi Reddy, Anna Pulimood, Kunissery A. Balasubramanian

Journal:

Year:

2002

Language:

english

File:

PDF, 458 KB

english, 2002

25

Mitochondrial electron transport chain complex dysfunction in the colonic mucosa in ulcerative colitis

Srikanth Santhanam, Subapriya Rajamanickam, Anjan Motamarry, Balakrishnan S. Ramakrishna, Jayakumar G. Amirtharaj, Anup Ramachandran, Anna Pulimood, Aparna Venkatraman

Journal:

Inflammatory Bowel Diseases

Year:

2012

Language:

english

File:

PDF, 1.79 MB

english, 2012

26

The impact of partial manganese superoxide dismutase (SOD2)-deficiency on mitochondrial oxidant stress, DNA fragmentation and liver injury during acetaminophen hepatotoxicity

Anup Ramachandran, Margitta Lebofsky, Steven A. Weinman, Hartmut Jaeschke

Journal:

Toxicology and Applied Pharmacology

Year:

2011

Language:

english

File:

PDF, 986 KB

english, 2011

27

Mitochondria, nitric oxide, and cardiovascular dysfunction

Anup Ramachandran, Anna-Liisa Levonen, Paul S. Brookes, Erin Ceaser, Sruti Shiva, Maria Cecilia Barone, Victor Darley-Usmar

Journal:

Free Radical Biology and Medicine

Year:

2002

Language:

english

File:

PDF, 592 KB

english, 2002

28

Nitric Oxide Prevents Anoxia-Induced Apoptosis in Colonic HT29 Cells

Muniswamy Madesh, Anup Ramachandran, K.A. Balasubramanian

Journal:

Archives of Biochemistry and Biophysics

Year:

1999

Language:

english

File:

PDF, 371 KB

english, 1999

29

Protease Activation during Surgical Stress in the Rat Small Intestine

Anup Ramachandran, K.A. Balasubramanian

Journal:

Journal of Surgical Research

Year:

2000

Language:

english

File:

PDF, 230 KB

english, 2000

30

Nitric Oxide Protects the Intestine from the Damage Induced by Laparotomy and Gut Manipulation

Simmy Thomas, Anup Ramachandran, Susama Patra, S. Vidyasagar, K.A. Balasubramanian

Journal:

Journal of Surgical Research

Year:

2001

Language:

english

File:

PDF, 801 KB

english, 2001

31

Intestinal Mitochondrial Dysfunction in Surgical Stress

Anup Ramachandran, Susama Patra, K.A. Balasubramanian

Journal:

Journal of Surgical Research

Year:

2001

Language:

english

File:

PDF, 335 KB

english, 2001

32

Retinoid metabolism during development of liver cirrhosis

Sathish Kumar Natarajan, Simmy Thomas, Anup Ramachandran, Anna B. Pulimood, Kunnissery A. Balasubramanian

Journal:

Archives of Biochemistry and Biophysics

Year:

2005

Language:

english

File:

PDF, 349 KB

english, 2005

33

Fatty acids influence binding of cobalt to serum albumin in patients with fatty liver

G. Jayakumar Amirtharaj, Sathish Kumar Natarajan, Ashis Mukhopadhya, Uday George Zachariah, Sudheer K. Hegde, George Kurian, K.A. Balasubramanian, Anup Ramachandran

Journal:

Biochimica et Biophysica Acta (BBA) - Molecular Basis of Disease

Year:

2008

Language:

english

File:

PDF, 332 KB

english, 2008

34

Current issues with acetaminophen hepatotoxicity—A clinically relevant model to test the efficacy of natural products

Hartmut Jaeschke, Mitchell R. McGill, C. David Williams, Anup Ramachandran

Journal:

Year:

2011

Language:

english

File:

PDF, 1.02 MB

english, 2011

35

Attenuation of intestinal ischemia/reperfusion injury with sodium nitroprusside: studies on mitochondrial function and lipid changes

Muniswamy Madesh, Anup Ramachandran, Anna Pulimood, Markandeyulu Vadranam, K.A Balasubramanian

Journal:

Biochimica et Biophysica Acta (BBA) - Molecular Basis of Disease

Year:

2000

Language:

english

File:

PDF, 2.13 MB

english, 2000

36

Effect of surgical manipulation of the rat intestine on enterocyte populations

Thomas Simmy, Ramachandran Anup, Ramamoorthy Prabhu, Kunissery A. Balasubramanian

Journal:

Year:

2001

Language:

english

File:

PDF, 848 KB

english, 2001

37

Lysosomal Instability and Cathepsin B Release during Acetaminophen Hepatotoxicity

Benjamin L. Woolbright, Anup Ramachandran, Mitchell R. McGill, Hui-min Yan, Mary Lynn Bajt, Matthew R. Sharpe, John J. Lemasters, Hartmut Jaeschke

Journal:

Basic & Clinical Pharmacology & Toxicology

Year:

2012

Language:

english

File:

PDF, 551 KB

english, 2012

38

Cellular mechanisms of redox cell signalling: role of cysteine modification in controlling antioxidant defences in response to electrophilic lipid oxidation products

LEVONEN, Anna-Liisa, LANDAR, Aimee, RAMACHANDRAN, Anup, CEASER, Erin K., DICKINSON, Dale A., ZANONI, Giuseppe, MORROW, Jason D., DARLEY-USMAR, Victor M.

Journal:

Biochemical Journal

Year:

2004

Language:

english

File:

PDF, 349 KB

english, 2004

39

Low dose aspirin prevents duodenoesophageal reflux induced mucosal changes in wistar rat esophagus by MAP kinase mediated pathways

Ben Selvan, Anup Ramachandran, Anu Korula, G. Jayakumar Amirtharaj, Kavithapriya Kettimuthu, Sheila Nair, Aravindan Nair, Prasanna Samuel, George Mathew

Journal:

International Journal of Surgery

Year:

2012

Language:

english

File:

PDF, 897 KB

english, 2012

40

Oxidative stress–associated hypertension in surgically induced brain injury patients: Effects of β-blocker and angiotensin-converting enzyme inhibitor

Parthiban K. Velayutham, Sanjib Das Adhikary, Srinivasa K. Babu, Rajshekhar Vedantam, Grace Korula, Anup Ramachandran

Journal:

Journal of Surgical Research

Year:

2013

Language:

english

File:

PDF, 510 KB

english, 2013

41

Acetaminophen-induced liver injury in rats and mice: Comparison of protein adducts, mitochondrial dysfunction, and oxidative stress in the mechanism of toxicity

Mitchell R. McGill, C. David Williams, Yuchao Xie, Anup Ramachandran, Hartmut Jaeschke

Journal:

Toxicology and Applied Pharmacology

Year:

2012

Language:

english

File:

PDF, 1.19 MB

english, 2012

42

Models of drug-induced liver injury for evaluation of phytotherapeutics and other natural products

Jaeschke, Hartmut, Williams, C. David, McGill, Mitchell R., Xie, Yuchao, Ramachandran, Anup

Journal:

Food and Chemical Toxicology

Year:

2013

Language:

english

File:

PDF, 505 KB

english, 2013

43

Osteopontin is an initial mediator of inflammation and liver injury during obstructive cholestasis after bile duct ligation in mice

Yang, Min, Ramachandran, Anup, Yan, Hui-Min, Woolbright, Benjamin L., Copple, Bryan L., Fickert, Peter, Trauner, Michael, Jaeschke, Hartmut

Journal:

Toxicology Letters

Year:

2014

Language:

english

File:

PDF, 4.05 MB

english, 2014

44

Dimethylformamide interferes with Coomassie dye staining of proteins on blue native gel electrophoresis

Raghupathy, V., Oommen, Anna, Ramachandran, Anup

Journal:

Analytical Biochemistry

Year:

2014

Language:

english

File:

PDF, 386 KB

english, 2014

45

To Study the Prevalence of Hepatopulmonary Syndrome (HPS) and Role of Hydrogen Sulfide (H2S) in Its Pathogenesis

Bera, Chinmay, Goel, Ashish, Ramachandran, Jeyamani, Pati, Purendrakumar, Ramachandran, Anup, Balasubramanian, K.A., Eapen, C.E.

Journal:

Journal of Clinical and Experimental Hepatology

Year:

2014

Language:

english

File:

PDF, 72 KB

english, 2014

46

Pregnancy-Related Liver Disorders

Goel, Ashish, Jamwal, Kapil D., Ramachandran, Anup, Balasubramanian, Kunissery A., Eapen, Chundamannil E.

Journal:

Journal of Clinical and Experimental Hepatology

Year:

2014

Language:

english

File:

PDF, 811 KB

english, 2014

47

Cyclophilin D deficiency protects against acetaminophen-induced oxidant stress and liver injury

Ramachandran, Anup, Lebofsky, Margitta, Baines, Christopher P., Lemasters, John J., Jaeschke, Hartmut

Journal:

Free Radical Research

Year:

2011

Language:

english

File:

PDF, 427 KB

english, 2011

48

Absence of G1528C mutation in long-chain 3-hydroxyacyl-CoA dehydrogenase in four Indian patients with pregnancy-related liver disease

Raghupathy, V., Goel, Ashish, Thangaraj, Kavitha R., Eapen, C. E., Balasubramanian, K. A., Regi, Annie, Jose, Ruby, Benjamin, Santosh J., Ramachandran, Anup

Journal:

Indian Journal of Gastroenterology

Year:

2014

Language:

english

File:

PDF, 206 KB

english, 2014

49

Reactive Nitrogen Species in Acetaminophen-Induced Mitochondrial Damage and Toxicity in Mouse Hepatocytes: A Cautionary Note on the Impact of Cell Culture Conditions

Jaeschke, Hartmut, Yan, Hui-min, Ramachandran, Anup

Journal:

Chemical Research in Toxicology

Year:

2010

Language:

english

File:

PDF, 37 KB

english, 2010

50

Neurobiological Assessment of Regenerative Electrodes for Bidirectional Interfacing Injured Peripheral Nerves

Lago, Natalia, Udina, Esther, Ramachandran, Anup, Navarro, Xavier

Journal:

IEEE Transactions on Biomedical Engineering

Year:

2007

Language:

english

File:

PDF, 4.42 MB

english, 2007